Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia

نویسندگان

چکیده

Inflammatory cytokines have a role in triggering cell signals colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor cytokine (SOCs) JAK-STAT. SOCs2 protein is cytoplasmic that can inhibit activation JAK-STAT so it prevents cascade nucleus. This thought to decreased adenocarcinoma colorectal. Objectives: To reveal expression 37 paraffin block samples Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records histopathology was assessed by HE. evaluated immunohistochemistry using polyclonal antibody (bs-1896R). Cytoplasmic counted Image J software. Results: The average age 56.57 years, 21 (55.8%) male, depth invasion mostly tunica muscularis (T3), 7 cases malignancy (18.9%) poorly differentiated. 5 (13.5%). Conclusion: There small proportion adenocarcinoma.Keywords: protein, inhibitor, JAK-STAT,

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ژورنال

عنوان ژورنال: Jurnal Kesehatan Andalas

سال: 2022

ISSN: ['2301-7406', '2615-1138']

DOI: https://doi.org/10.25077/jka.v11i1.1982